December 1, 1988Journal of Cardiac Surgery
Aortic Valve Replacement with Stentless Porcine Bioprostheses
Why the study?
Does aortic valve replacement with a stentless porcine bioprosthesis provide good hemodynamic performance and resist calcification?
Population
Six young sheep and five humans undergoing aortic valve replacement
Design
Preclinical
Follow-up
3 to 6 months (for sheep)
Authors
Discussion
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Implication
Early sheep and human data support further evaluation; leaves open long-term durability and calcification resistance.
Structured PICO
Does aortic valve replacement with a stentless porcine bioprosthesis provide good hemodynamic performance and resist calcification?
P
Population
Six young sheep and five humans undergoing aortic valve replacement
I
Intervention
Aortic valve replacement with stentless glutaraldehyde-fixed aortic porcine bioprosthesis
O
Outcome
Hemodynamic performance (resting gradients, aortic regurgitation) and explant evaluation (healing, calcification) in sheep; clinical results in humanssurrogate
Stentless porcine bioprostheses demonstrate excellent early hemodynamic performance and lack of calcification in a sheep model, with promising initial results in humans.
Cite This Study
David et al. (1988) studied this question.