Key result
Novel porcine pericardial valve survives ~200 million in vitro cycles and functions normally in sheep.
Why the study?
Bioprosthetic leaflets from animal tissues are widely used in cardiac valve replacements, prompting the development of a new surgical bioprosthesis using porcine pericardial leaflets as an alternative to bovine pericardium and synthetic fabric.
Does a novel porcine pericardial surgical bioprosthetic heart valve demonstrate adequate hydrodynamics, durability, and acute in vivo performance in preclinical models?
Does a novel porcine pericardial surgical bioprosthetic heart valve demonstrate adequate hydrodynamics, durability, and acute in vivo performance in preclinical models?
A novel surgical bioprosthetic heart valve using genetically engineered porcine pericardium demonstrated excellent in vitro durability and acute in vivo performance, offering a proof-of-concept alternative to bovine pericardium.
Should not alter valve selection; leaves open long-term durability and human translation of porcine pericardial bioprostheses.
Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0.6% glutaraldehyde, and used to develop a new surgical valve design. The valves underwent in vitro hydrodynamic test in a pulse duplicator and high-cycled accelerated wear testing and were evaluated for acute haemodynamics and thrombogenicity in a juvenile sheep implant study for 48 h. The porcine surgical pericardial heart valves (pSPHVs) exhibited excellent hydrodynamics and reached 200 million cycles of in vitro durability, with no observable damage. Juvenile sheep implants demonstrated normal valve function with no acute thrombogenic response for either material. The pSPHV incorporates a minimalistic construction method using a tissue-to-tissue design to cover the stent. This new design is a proof of concept alternative to the use of bovine pericardium and synthetic fabric in surgical bioprosthetic heart valves.
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Rahmani et al. (2019) studied Preclinical evaluation of bioprosthetic heart valve (n=2). Porcine surgical pericardial heart valve (pSPHV) was evaluated on Valve function and thrombogenicity. The novel porcine surgical pericardial heart valve demonstrated excellent hydrodynamics, survived 200 million in vitro cycles without damage, and showed normal function in a 48-hour sheep model.
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