What question did this study set out to answer?

To isolate and structurally characterize halogenated monoterpenes from the marine red alga Portieria hornemannii and determine their inhibitory effects on DNA methyltransferase-1.

February 15, 2006Journal of Natural Products

DNA Methyl Transferase Inhibiting Halogenated Monoterpenes from the Madagascar Red Marine Alga Portieria hornemannii

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Authors

EAEric H. AndrianasoloUniversity of Waterloo DFDennis S. FranceNovartis (Switzerland)SCSusan Cornell-KennonAdvanced Cell Technology (United States)

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Implication

Biochemical analysis reveals DNA methyltransferase-1 inhibition by red alga halogenated monoterpenes, highlighting potential marine-derived epigenetic therapeutics.

Key Points

To isolate and structurally characterize halogenated monoterpenes from the marine red alga Portieria hornemannii and determine their inhibitory effects on DNA methyltransferase-1.
Extracted and isolated secondary metabolites from specimens of the Madagascar red marine alga Portieria hornemannii.
Elucidated the chemical structures of new compounds using nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry.
Assayed the isolated monoterpenes in vitro for inhibitory activity against DNA methyltransferase-1 (DNMT1).
Isolated three novel halogenated monoterpenes along with the known compound halomon and two of its analogues.
Demonstrated that halomon and one newly isolated monoterpene inhibit DNA methyltransferase-1 at low micromolar concentrations.

Cite This Study

Andrianasolo et al. (2006) studied this question.

synapsesocial.com/papers/6a7dff95d491aa75eb151b2b https://doi.org/10.1021/np0503956

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Implication

Biochemical analysis reveals DNA methyltransferase-1 inhibition by red alga halogenated monoterpenes, highlighting potential marine-derived epigenetic therapeutics.

DNA Methyl Transferase Inhibiting Halogenated Monoterpenes from the Madagascar Red Marine Alga Portieria hornemannii

Discussion

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Implication

Key Points

Cite This Study

DNA Methyl Transferase Inhibiting Halogenated Monoterpenes from the Madagascar Red Marine Alga Portieria hornemannii

Discussion

Member takes

Implication

Key Points

Cite This Study

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