Population
Human intestinal epithelial Caco-2 cells
Comparison
Rotavirus (RRV) infection vs Mock-infected / uninfected Caco-2 cells
Design
Preclinical
Follow-up
Up to 24 hours post-infection
Authors
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Calcium dysregulation may contribute to rotavirus enteropathy in models; leaves open human translation and therapeutic targeting.
Rotavirus infection of human intestinal epithelial cells causes an increase in intracellular calcium that drives microvillar F-actin disassembly.
Brunet et al. (2000) studied this question.
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