Population
MA-104 cells infected with rotavirus
Comparison
Thapsigargin (0.1 to 1 microM) vs Untreated infected cells
Design
Preclinical
Authors
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Thapsigargin may inhibit rotavirus via ER calcium depletion; hypothesis-generating for antiviral targets but should not yet change practice.
Rotavirus maturation requires high sequestered calcium in the endoplasmic reticulum, whereas virus-induced cell death is independent of mature particle production.
Michelangeli et al. (1995) studied this question.
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