Key result
Rotavirus infection of cultured cells activates a cation channel, increasing permeability to Ca2+ and other divalent cations, which is partially inhibited by L-type channel blockers.
Population
Cultured MA104 and HT29 cells in suspension
Design
Preclinical
Authors
Loading...
May link Ca2+ influx to rotavirus maturation; leaves open in vivo relevance and L-type blocker utility.
Rotavirus infection activates a cation channel in cultured cells, increasing intracellular Ca2+ which may be required for virus maturation and cell death.
Perez‐Zoghbi et al. (1999) studied Rotavirus infection in cultured cells. Rotavirus infection was evaluated on Intracellular Ca2+ permeability and cation entry pathway. Rotavirus infection of cultured cells activates a cation channel, increasing permeability to Ca2+ and other divalent cations, which is partially inhibited by L-type channel blockers.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: