Population
4 puppies inoculated in utero with canine myocarditis virus 8 days before parturition
Design
Preclinical
Follow-up
up to 131 days post inoculation
Authors
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Animal model confirms parvovirus myocardial tropism; leaves open translation to human viral myocarditis.
Intrauterine inoculation of canine parvovirus in puppies leads to acute myocarditis or chronic myocardial fibrosis, demonstrating a predilection for cardiac myocytes.
Lenghaus et al. (1980) studied this question.
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