Why the study?
Does renal dysfunction alter the elimination and responsiveness to a single oral dose of warfarin compared to normal controls?
Does renal dysfunction alter the elimination and responsiveness to a single oral dose of warfarin compared to normal controls?
Patients with renal dysfunction have a shorter warfarin half-life but comparable pharmacologic responsiveness to normal controls, suggesting no increased susceptibility to its hypoprothrombinemic effects.
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Shorter warfarin half-life in renal impairment does not increase responsiveness; hypothesis-generating for dosing in CKD and needs prospective confirmation.
Bachmann et al. (1977) studied this question.
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