Key result
Oral warfarin absorption was rapid, with peak plasma concentrations reached by 25 to 60 minutes and 77.6% to 100% of the dose absorbed based on plasma concentration-time curves.
Why the study?
What are the kinetics of oral warfarin absorption in humans?
Population
8 human subjects
Design
Other
Follow-up
Up to 120 minutes
Authors
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Warfarin absorption data may inform early monitoring timing; leaves open variability in broader clinical populations.
What are the kinetics of oral warfarin absorption in humans?
Oral warfarin is rapidly and extensively absorbed in humans, reaching peak plasma concentrations within 25 to 60 minutes.
Breckenridge et al. (1973) studied this question. Oral warfarin was evaluated on Percentage of oral dose absorbed and rate of absorption. Oral warfarin absorption was rapid, with peak plasma concentrations reached by 25 to 60 minutes and 77.6% to 100% of the dose absorbed based on plasma concentration-time curves.
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