Why the study?
Does exposure to an operating-room environment alter warfarin kinetics and prothrombin response in humans?
Population
12 subjects (5 normal, nonmedicated controls and 7 anesthesiology residents)
Comparison
Exposure to an operating-room environment for 4… vs No exposure to operating-room environment
Design
Cohort
Follow-up
4 months
Authors
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OR exposure was associated with altered warfarin kinetics in residents; hypothesis-generating for environmental drug effects and should not yet change practice.
Does exposure to an operating-room environment alter warfarin kinetics and prothrombin response in humans?
Exposure to an operating-room environment significantly prolongs warfarin half-life and increases prothrombin response, likely due to inhibition of warfarin metabolism.
Ghoneim et al. (1975) studied this question.
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