Population
10 compliant patients taking therapeutic doses of racemic warfarin with stable anticoagulation status…
Design
Cross-sectional
Follow-up
24 hours
Authors
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Steady-state AUC-derived warfarin clearances may differ from single-point estimates; leaves open whether enantiomer-specific values improve dosing accuracy.
Steady-state clearance rates of warfarin enantiomers derived from AUC data in compliant patients differ from single-point determinations, highlighting the inaccuracy of assuming a 12-hour postdose sample represents steady-state concentration.
McAleer et al. (1997) studied this question.
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