Why the study?
Is there an intrasubject correlation between the pharmacokinetics of warfarin enantiomers and racemic warfarin in healthy men?
Population
10 healthy men, aged 21 to 51 years
Comparison
Single doses of R(+)-, S(-)-, and racemic warfarin vs Intrasubject comparison between enantiomers and…
Design
Other
Authors
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Racemic dose may estimate S-warfarin needs in healthy subjects; leaves open clinical translation and patient outcomes.
Is there an intrasubject correlation between the pharmacokinetics of warfarin enantiomers and racemic warfarin in healthy men?
The maintenance dose of racemic warfarin is a useful predictor for the required dose of S(-)-warfarin to achieve comparable anticoagulation, but not for R(+)-warfarin.
Wingard et al. (1978) studied this question.
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