Key result
Rifampin significantly reduces plasma warfarin levels and prothrombin time compared to warfarin alone.
Why the study?
Does rifampin reduce the hypoprothrombinemic effect and plasma concentration of warfarin in normal subjects?
Population
n=10 normal subjects
Comparison
Rifampin 600 mg orally once daily combined with… vs Single doses of warfarin alone administered by…
Design
Other
Follow-up
duration of the hypoprothrombinemia
Authors
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Rifampin may attenuate warfarin effect via enhanced clearance; leaves open interaction magnitude and management in anticoagulated patients.
Does rifampin reduce the hypoprothrombinemic effect and plasma concentration of warfarin in normal subjects?
p-value: p=<0.001
Rifampin significantly decreases the hypoprothrombinemic effect and plasma concentration of warfarin, likely by enhancing its elimination from the body.
Robert A. O’Reilly (1974) studied Healthy volunteers (n=10). Rifampin vs. Warfarin alone was evaluated on Mean area of the one-stage prothrombin time and mean area of warfarin in plasma (p=<0.001). Rifampin therapy significantly decreased both the mean area of the one-stage prothrombin time and the mean area of warfarin in plasma (P<0.001 for both) compared to warfarin alone.
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