Key result
Simultaneous rifampin linked to failed therapeutic warfarin anticoagulation due to extremely high clearance.
Why the study?
The warfarin-rifampin interaction is a well-described but underappreciated drug interaction affecting anticoagulation efficacy.
Does simultaneous administration of rifampin affect the ability to attain therapeutic anticoagulation with warfarin?
Population
A patient receiving simultaneous warfarin and rifampin therapy
Comparison
Warfarin therapy with and without rifampin co-administration
Design
Case report
Follow-up
Nearly 4 weeks
Authors
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Rifampin may preclude therapeutic warfarin anticoagulation; extends known interaction but leaves open optimal management strategies.
Case Report (n=1)
Does simultaneous administration of rifampin affect the ability to attain therapeutic anticoagulation with warfarin?
Simultaneous administration of rifampin can severely increase warfarin clearance, preventing the attainment of therapeutic anticoagulation and requiring significant dosage adjustments.
Paul R. Casner (1996) conducted a case report in Warfarin-rifampin drug interaction (n=1). Simultaneous administration of warfarin and rifampin was evaluated on Therapeutic anticoagulation. Simultaneous administration of rifampin resulted in the inability to achieve therapeutic anticoagulation after nearly 4 weeks of warfarin therapy due to extremely high warfarin clearance.
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