Why the study?
The drug-drug interaction between warfarin and rifampin is well documented, but literature and published case reports describing the interaction between warfarin and rifabutin are lacking.
Does switching from rifampin to rifabutin improve the ability to achieve therapeutic anticoagulation with warfarin in a patient with pulmonary embolism and tuberculosis?
Does switching from rifampin to rifabutin improve the ability to achieve therapeutic anticoagulation with warfarin in a patient with pulmonary embolism and tuberculosis?
Switching from rifampin to rifabutin may allow for successful therapeutic anticoagulation with warfarin by minimizing drug-drug interactions.
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May support rifabutin substitution for therapeutic INR on warfarin; hypothesis-generating case report requiring confirmation.
Alnewais et al. (2023) studied this question.
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