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Real‐World Evaluation of the Interaction Between Rifampicin and Warfarin: A Retrospective Observational Study

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Retrospective analysis reveals significant drug-drug interactions with warfarin, suggesting careful monitoring.

A notable 86.3% of patients experienced a drug-drug interaction with warfarin and rifampicin, impacting INR levels significantly.
Patients on concurrent warfarin and rifampicin had a median INR decrease to 1.3, indicating reduced effectiveness of warfarin.
With individualized treatment plans, some patients reached the target INR, yet 31% did not despite increased warfarin dosages.
Close monitoring during treatment with these medications is essential to ensure patient safety and health outcomes.

Naseralallah et al. (2025) studied this question.

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