July 1, 2003Journal of Cardiovascular Electrophysiology
Ambulatory Electrocardiogram‐Based Tracking of T Wave Alternans in Postmyocardial Infarction Patients to Assess Risk of Cardiac Arrest or Arrhythmic Death
Why the study?
Does elevated T wave alternans on ambulatory ECG predict cardiac arrest or arrhythmic death in post-myocardial infarction patients?
Population
44 post-myocardial infarction patients from the ATRAMI prospective study of 1,284 patients. Cases and…
Comparison
T wave alternans magnitude >75th percentile… vs T wave alternans (TWA) magnitude ≤75th percentile
Design
Case-control
Follow-up
21 +/- 8 months
Authors
Discussion
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Member takes
Implication
Elevated ambulatory TWA may aid post-MI arrhythmic risk stratification; leaves open its incremental value and requires prospective validation before clinical adoption.
Structured PICO
Does elevated T wave alternans on ambulatory ECG predict cardiac arrest or arrhythmic death in post-myocardial infarction patients?
P
Population
44 post-myocardial infarction patients (15 cases who experienced cardiac arrest or arrhythmic death and 29 controls) from the ATRAMI prospective study of 1,284 patients. Cases and controls were matched for sex, age, site of MI, left ventricular ejection fraction, thrombolysis, and beta-blockade therapy.
I
Intervention
T wave alternans (TWA) magnitude >75th percentile measured from 24-hour ambulatory electrocardiograms using modified moving average (MMA) analysis
C
Comparator
T wave alternans (TWA) magnitude ≤75th percentile
O
Outcome
Cardiac arrest due to documented ventricular fibrillation or arrhythmic deathhard clinical
T wave alternans measurement from routine 24-hour ambulatory ECGs is a promising approach for risk stratification of cardiac arrest and arrhythmic death in post-MI patients.
Cite This Study
Verrier et al. (2003) studied this question.