Key result
Ambulatory ECG-based T-wave alternans above the optimal cutpoint strongly predicted sudden cardiac death in high-risk post-MI patients (RR 7.1; 95% CI 2.7-18.3; P<0.001).
Why the study?
Does ambulatory ECG-based T-wave alternans predict sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction?
Population
138 hospitalized post-MI patients with heart failure and/or diabetes with left ventricular dysfunction from…
Comparison
Ambulatory ECG-based T-wave alternans measured… vs Lower TWA values
Design
Case-control
Authors
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Should not yet alter ICD decisions in post-MI LV dysfunction; leaves open whether T-wave alternans refines sudden death prediction.
Case-Control (n=138)
Does ambulatory ECG-based T-wave alternans predict sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction?
Relative Risk: 7.1 (95% CI 2.7–18.3)
p-value: p=< 0.001
Ambulatory ECG-based T-wave alternans measured with the modified moving average method is a powerful predictor of sudden cardiac death in high-risk post-MI patients with LV dysfunction.
Stein et al. (2008) conducted a case-control in Post-MI with left ventricular dysfunction (n=138). Ambulatory ECG-based T-wave alternans (TWA) vs. TWA below cutpoint was evaluated on Sudden cardiac death (SCD) (RR 7.1, 95% CI 2.7-18.3, p=< 0.001). Ambulatory ECG-based T-wave alternans above the optimal cutpoint strongly predicted sudden cardiac death in high-risk post-MI patients (RR 7.1; 95% CI 2.7-18.3; P<0.001).
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