Population
Guinea pig papillary muscle and dog Purkinje fiber
Comparison
MDL 11,939 hydrochloride (10^-7 to 10^-5 M) vs Bretylium, clofilium, and d-sotalol
Design
Preclinical
Authors
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Preclinical data on MDL 11,939 are hypothesis-generating for class III activity; should not inform clinical antiarrhythmic decisions.
MDL 11,939 exhibits cellular electrophysiological properties consistent with class III antiarrhythmic activity, including increasing action potential duration and producing negative inotropic effects.
Li et al. (1990) studied this question.
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