Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury
Why the study?
Does perioperative aspirin or clonidine reduce the risk of acute kidney injury in patients undergoing noncardiac surgery?
Population
6,905 patients undergoing noncardiac surgery from 88 centers in 22 countries
Comparison
Aspirin and/or Clonidine vs Matching placebo
Design
RCT, 2 × 2 factorial randomized, blinded
Follow-up
up to 30 days
Authors
Discussion
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Member takes
Implication
Clinicians should not use perioperative aspirin or clonidine to prevent acute kidney injury; confirms no renal benefit in this noncardiac surgery RCT.
Structured PICO
Does perioperative aspirin or clonidine reduce the risk of acute kidney injury in patients undergoing noncardiac surgery?
P
Population
6,905 patients undergoing noncardiac surgery from 88 centers in 22 countries
I
Intervention
Aspirin (200 mg 2-4 hours before surgery, then 100 mg daily up to 30 days) and/or Clonidine (0.2 mg oral 2-4 hours before surgery, then transdermal patch 0.2 mg/d until 72 hours after surgery)
C
Comparator
Matching placebo
O
Outcome
Acute kidney injury (increase in serum creatinine concentration from preoperative concentration by ≥0.3 mg/dL within 48 hours or ≥50% within 7 days of surgery)surrogate
Perioperative administration of aspirin or clonidine does not reduce the risk of acute kidney injury in patients undergoing noncardiac surgery and is associated with increased risks of bleeding and hypotension.
Cite This Study
Garg et al. (2014) studied this question.