The proposed Japanese guidelines recommend using non-HDL cholesterol as a secondary target for patients with hypertriglyceridemia after achieving LDL cholesterol goals.
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Non-HDL cholesterol differentiates subgroups in type IIb hyperlipidemia; reinforces its use as secondary target in Japanese guidelines.
The Japan Atherosclerosis Society (JAS) guidelines for the prevention of atherosclerotic diseases, proposing management for LDL cholesterol as the primary target, have successfully contributed to the prevention of cardiovascular events; however, recently, the impact of hypertriglyceridemia as an additional cardiovascular risk has become understood, especially in light of the rise in obesity, metabolic syndrome, and diabetes in the Japanese population. Rather than waiting to obtain conclusive domestic data confirming that hypertriglyceridemia is a cardiovascular risk factor and that its management is efficacious, we propose guidelines for hypertriglyceridemia using non-HDL cholesterol as a second target.
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Shimano et al. (2008) studied this question.
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