What question did this study set out to answer?

To evaluate how hospital antibiotic prescription patterns influence the competitive selection and invasion of community-associated methicillin-resistant Staphylococcus aureus against other circulating staphylococcal strains.

July 26, 2011Antimicrobial Agents and ChemotherapyOpen Access

Impact of Antibiotic Exposure Patterns on Selection of Community-Associated Methicillin-Resistant Staphylococcus aureus in Hospital Settings

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Authors

LKLidia Kardaś-SłomaAssistance Publique – Hôpitaux de Paris PBPierre‐Yves BoëlleInserm LOLulla OpatowskiInserm

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Implication

Mathematical modeling study demonstrates how antibiotic exposure patterns drive community-associated MRSA selection in hospital wards, indicating that targeted stewardship can limit hospital spread.

Key Points

To evaluate how hospital antibiotic prescription patterns influence the competitive selection and invasion of community-associated methicillin-resistant Staphylococcus aureus against other circulating staphylococcal strains.
Developed a computerized agent-based transmission model of S. aureus cocirculation among CA-MRSA, MSSA, and HA-MRSA strains within hospital wards.
Simulated diverse antibiotic prescription patterns across intensive care units and general wards reflecting exposure variations across European and United States hospitals.
Simulated endemic prevalence of CA-MRSA carriage in intensive care units varied between 3% and 20%, dictated by the specific antibiotic prescription pattern.
Extensive exposure to antibiotics active against MSSA but ineffective against MRSA promoted competitive hospital invasion by CA-MRSA.
Simulations demonstrated that potential acquisition of fluoroquinolone resistance by CA-MRSA would trigger a major surge in CA-MRSA prevalence across hospitals worldwide.

Cite This Study

Kardaś-Słoma et al. (2011) studied this question.

synapsesocial.com/papers/6a7e0bf0cf7e8b32dacb5e17 https://doi.org/10.1128/aac.01626-10

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Implication

Mathematical modeling study demonstrates how antibiotic exposure patterns drive community-associated MRSA selection in hospital wards, indicating that targeted stewardship can limit hospital spread.

Impact of Antibiotic Exposure Patterns on Selection of Community-Associated Methicillin-Resistant Staphylococcus aureus in Hospital Settings

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of Antibiotic Exposure Patterns on Selection of Community-Associated Methicillin-Resistant Staphylococcus aureus in Hospital Settings

Discussion

Member takes

Implication

Key Points

Cite This Study

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