Why the study?
Are ventricular microsomal triglyceride transfer protein and apoB mRNA levels higher in patients undergoing CABG compared to valve replacement surgery?
Are ventricular microsomal triglyceride transfer protein and apoB mRNA levels higher in patients undergoing CABG compared to valve replacement surgery?
Cardiac lipoprotein production is increased in hypoxic human ventricles, which may attenuate triglyceride accumulation in cardiac myocytes.
Supports hypothesis of increased cardiac lipoprotein production in ischemic ventricles; leaves open whether this attenuates myocyte triglyceride accumulation.
OBJECTIVES: Cardiac myocytes secrete apolipoprotein (apo)B-containing lipoproteins. Their function may be the removal of triglycerides when beta-oxidation of fatty acids is decreased, eg, during hypoxia. To test this hypothesis, we examined heart biopsies from patients undergoing coronary artery bypass graft (CABG, n=13) or valve replacement (n=6) surgery. METHODS AND RESULTS: Ventricular microsomal triglyceride transfer protein (P=0.02) and apoB (P=0.04) mRNA levels were both approximately 2-fold higher in CABG compared with valve replacement patients. In CABG patients, ventricular microsomal triglyceride transfer protein mRNA levels were negatively associated with the triglyceride content in ventricular myocytes (r=-0.70; P=0.02) and with mRNA levels of sterol regulatory element binding protein-1 (r=-0.74; P=0.004). CONCLUSIONS: The results are compatible with the notion that cardiac lipoprotein production is increased in hypoxic human ventricle, possibly as a result of decreased sterol regulatory element binding protein-1 expression. This might attenuate accumulation of triglycerides in cardiac myocytes.
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Nielsen et al. (2002) studied this question.