Why the study?
Does elevated glucose stimulate endothelin-1 release in cultured bovine aortic endothelial cells?
Does elevated glucose stimulate endothelin-1 release in cultured bovine aortic endothelial cells?
Hyperglycemia may enhance endothelin-1 release at the vascular endothelium, potentially contributing to diabetic vascular complications and atherosclerosis.
High glucose may enhance endothelial ET-1 release; hypothesis-generating for diabetic vasculopathy, requiring in vivo confirmation.
We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-1-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release. These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium, which might be involved in the developments of vascular complications and atherosclerosis.
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Yamauchi et al. (1990) studied this question.
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