Why the study?
Does converting-enzyme inhibition alter creatinine clearance in patients with severe chronic heart failure?
Does converting-enzyme inhibition alter creatinine clearance in patients with severe chronic heart failure?
In severe heart failure with low renal perfusion pressure, converting-enzyme inhibition reduces glomerular filtration rate specifically in patients with high baseline plasma renin activity, indicating that angiotensin II supports their renal function.
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May reduce GFR in severe HF with low perfusion and high renin; hypothesis-generating for renin-stratified ACEI strategies.
Packer et al. (1986) studied this question.