January 1, 2014Genetics and Molecular ResearchOpen Access

Interaction of six candidate genes in essential hypertension

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Population

197 individuals from the Han population in Yunnan Province, China, comprising 100 patients with essential…

Design

Case-control

Authors

DHDeming HuZunyi Medical University XZXiaoli ZhaoHangzhou Hospital of Traditional Chinese Medicine JSJianchun ShaoFujian Petrochemical Group (China)

Discussion

Member takes

Implication

May inform genetic risk models for essential hypertension; leaves open replication and clinical utility in prospective cohorts.

Structured PICO

Population

197 individuals from the Han population in Yunnan Province, China, comprising 100 patients with essential hypertension (EH) and 97 controls.

Comparator

97 controls without essential hypertension

Outcome

Association of 6 candidate genetic mutations (AGT M235T, ACE I/D, eNOS Glu298Asp, ET-2 A985G, ANP T2238C, and NPRC A-55C) and their interactions with the risk of essential hypertensionsurrogate

The CC genotype for NPRC A-55C and its interaction with the ET-2 A985G G allele are associated with increased susceptibility to essential hypertension in a Chinese Han population.

Cite This Study

Hu et al. (2014) studied this question.

synapsesocial.com/papers/6a7e138cefb6c265945bf88d https://doi.org/10.4238/2014.october.20.14

Topics

Hypertension management

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Interaction of six candidate genes in essential hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Interaction of six candidate genes in essential hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider