Why the study?
Does intracellular injection of PKC subtypes modulate voltage-dependent transient K+ and Na+ channels in Xenopus oocytes expressing chick brain RNA?
Population
Xenopus oocytes injected with chick brain RNA
Comparison
Intracellular injection of purified subtypes I… vs Inactivated or unactivated enzyme and vehicle…
Design
Preclinical
Authors
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No immediate clinical relevance; leaves open PKC subtype selectivity for neuronal channel modulation in mammalian systems.
Does intracellular injection of PKC subtypes modulate voltage-dependent transient K+ and Na+ channels in Xenopus oocytes expressing chick brain RNA?
This study demonstrates that voltage-dependent Na+ and K+ channels in vertebrate neurons are differentially modulated by specific subtypes of protein kinase C.
Lotan et al. (1990) studied this question.
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