Why the study?
Does activation of PKC by PMA modulate cardiac L-type Ca2+ currents in Xenopus oocytes?
Population
Xenopus laevis oocytes injected with RNAs coding for different cardiac Ca2+ channel subunits, or with total…
Comparison
Activation of protein kinase C by the phorbol… vs Staurosporine or baseline
Design
Preclinical
Authors
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PKC modulation of L-type Ca currents via alpha1 in oocytes leaves open translation to native mammalian cardiomyocytes and any therapeutic relevance.
Does activation of PKC by PMA modulate cardiac L-type Ca2+ currents in Xenopus oocytes?
Both enhancement and inhibition of cardiac L-type Ca2+ currents by PKC are mediated via an effect on the alpha 1 subunit, while the beta subunit plays a mild modulatory role.
Singer‐Lahat et al. (1992) studied this question.
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