Population
In vitro models using Baby hamster fibroblast cells, Lec-2 cells, and human type O erythrocytes infected…
Comparison
Site-directed mutagenesis of VP2 puff B amino… vs Parental BeAn virus and non-infectious BeAn clone.
Design
Preclinical
Authors
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Does not support clinical translation; leaves open whether these residues are viable antiviral targets in vivo.
Amino acid substitutions in the VP2 sialic acid-binding residues of the BeAn virus dramatically reduce viral binding and spread, demonstrating the necessity of these contacts for viral entry.
Kumar et al. (2003) studied this question.
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