Population
Mice inoculated intracerebrally with Theiler's murine encephalomyelitis virus
Design
Preclinical
Authors
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Attenuated phenotypes from AUG mutations in animals warrant caution for vaccine translation; leaves open their broader role in viral pathogenesis.
Point mutations changing the context of an AUG within the starting window of viral RNA can result in distinct attenuation phenotypes and affect morbidity and mortality.
Pilipenko et al. (1999) studied this question.
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