February 1, 1995Journal of VirologyOpen Access

Attenuation of Theiler's murine encephalomyelitis virus by modifications of the oligopyrimidine/AUG tandem, a host-dependent translational cis element

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Population

BHK-21 cells and mice

Design

Preclinical

Authors

EPEvgeny V. PilipenkoUniversity of Chicago AGAnatoly P. GmylRussian Academy of Sciences SMSvetlana V. MaslovaAcademy of Medical Sciences

Discussion

Member takes

Implication

Attenuates TMEV neurovirulence in mice; leaves open cis-element targeting for picornavirus vaccines pending human model validation.

Structured PICO

Population

BHK-21 cells and mice

Intervention

Theiler's murine encephalomyelitis virus mutants with engineered alterations in the conserved oligopyrimidine/AUG tandem

Outcome

Growth potential in BHK-21 cells (plaque size) and neurovirulence upon intracerebral inoculation of mice

The oligopyrimidine/AUG tandem is a host-dependent cis-acting control element essential for Theiler's murine encephalomyelitis virus neurovirulence in mice but dispensable for growth in BHK-21 cells.

Cite This Study

Pilipenko et al. (1995) studied this question.

synapsesocial.com/papers/6a72dd8d6200647efb1ae6ee https://doi.org/10.1128/jvi.69.2.864-870.1995

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Attenuation of Theiler's murine encephalomyelitis virus by modifications of the oligopyrimidine/AUG tandem, a host-dependent translational cis element

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Attenuation of Theiler's murine encephalomyelitis virus by modifications of the oligopyrimidine/AUG tandem, a host-dependent translational cis element

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider