Population
Theiler's murine encephalomyelitis virus genome, BHK-21 cells, L929 cells, and mice
Comparison
Nonpolar mutations introduced into all 12… vs Wild-type virus or other regional mutations
Design
Preclinical
Authors
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2A deletion attenuates Theiler's virus in mice without impairing replication; leaves open its role in virulence factor targeting for further preclinical study.
Protein 2A is dispensable for Theiler's virus RNA replication but is required for virulence in mice and propagation in certain cell lines.
Michiels et al. (1997) studied this question.
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