Population
BHK-21 cells and 6- to 8-week-old SJL/J mice (5-10 mice per dilution)
Comparison
Inoculation with RNA transcripts derived from… vs Parental TMEV strains and DMEM control
Design
Preclinical
Follow-up
up to 16 days post-infection
Authors
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Does not inform human viral encephalomyelitis management; leaves open TMEV attenuation targets for future murine vaccine studies.
The study identifies the L/P1 and 5' noncoding regions of the TMEV genome as primary determinants of neurovirulence and attenuation in a murine model.
Calenoff et al. (1990) studied this question.
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