What does this research mean for the field?

Specific amino acid substitutions in loop I of the VP1 capsid protein and the pit wall of Theiler's murine encephalomyelitis virus alter viral tropism and attenuate both acute and chronic demyelinating pathogenesis in mice. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1999Journal of VirologyOpen Access

Theiler’s Viruses with Mutations in Loop I of VP1 Lead to Altered Tropism and Pathogenesis

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Population

Susceptible mice (model for human demyelinating diseases such as multiple sclerosis)

Comparison

DA virus mutants with specific mutations in the… vs Wild-type DA virus

Design

Preclinical

Authors

IMIngeborg J. McCrightJackson Laboratory ITIkuo TsunodaKindai University FWFrank G. WhitbyUniversity of Utah

Discussion

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Implication

VP1 mutations modulate Theiler's virus pathogenesis in mice; leaves open relevance to human demyelinating disease.

Structured PICO

Population

Susceptible mice (model for human demyelinating diseases such as multiple sclerosis)

Intervention

DA virus mutants with specific mutations in the viral capsid protein VP1 (T81D, T81V, T81W, V91T)

Comparator

Wild-type DA virus

Outcome

Viral tropism and pathogenesis (development of acute polioencephalomyelitis and chronic demyelinating disease)surrogate

Mutations in loop I of VP1 and the wall of the pit in Theiler's virus alter virus-host interactions, affecting viral tropism and pathogenesis in a mouse model of demyelinating disease.

Cite This Study

McCright et al. (1999) studied this question.

synapsesocial.com/papers/6a1d75331c2cbcb15c5e57d8 https://doi.org/10.1128/jvi.73.4.2814-2824.1999

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Theiler’s Viruses with Mutations in Loop I of VP1 Lead to Altered Tropism and Pathogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Theiler’s Viruses with Mutations in Loop I of VP1 Lead to Altered Tropism and Pathogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider