Population
In vitro cell lines and in vivo 3-week-old female SJL mice
Comparison
Infection with CHO-K1-adapted Theiler's murine… vs Infection with wild-type parental TMEV strains
Design
Preclinical
Follow-up
Up to 45 days in vivo
Authors
Loading...
Single VP1 mutation abolishes mouse neurovirulence; leaves open whether sialic acid binding modulates Theiler's virus persistence in vivo.
Capsid mutations affecting in vitro tropism and sialic acid binding dramatically alter the persistence and neurovirulence of Theiler's virus in mice.
Jnaoui et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: