April 1, 1991Journal of VirologyOpen Access

Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection

Q: What is the clinical evidence from this study?

Study design: Other. Population: Theiler's murine encephalomyelitis virus infection. Intervention: Mutated virus OSM101 (amino acid substitution at position 101 of VP-1) vs. Control virus DAFL3. Primary outcome: Neurovirulence, infectious virus levels, and number of infected cells in central nervous system tissues.

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Key result

Virus OSM101 with a single amino acid substitution at position 101 of VP-1 was markedly less neurovirulent in mice than the control virus DAFL3.

Authors

AZAndreas ZurbriggenNihon University CTCharles C. ThomasNational Academy of Governance MYMasahito YamadaTokyo Medical and Dental University

Discussion

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Implication

Highlights VP-1 position 101 for murine neurovirulence; leaves open human disease relevance.

PICO

Population

Theiler's murine encephalomyelitis virus infection

Intervention / Comparator

Mutated virus OSM101 (amino acid substitution at position 101 of VP-1) vs Control virus DAFL3

Primary Outcome

Neurovirulence, infectious virus levels, and number of infected cells in central nervous system tissues

Cite This Study

Zurbriggen et al. (1991) studied Theiler's murine encephalomyelitis virus infection. Mutated virus OSM101 (amino acid substitution at position 101 of VP-1) vs. Control virus DAFL3 was evaluated on Neurovirulence, infectious virus levels, and number of infected cells in central nervous system tissues. Virus OSM101 with a single amino acid substitution at position 101 of VP-1 was markedly less neurovirulent in mice than the control virus DAFL3.

synapsesocial.com/papers/6a6e82a8e5469ee92be003fe https://doi.org/10.1128/jvi.65.4.1929-1937.1991

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Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection

Discussion

Member takes

Implication

PICO

Cite This Study

Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider