Population
Mice infected with Theiler's virus strains (DA, GDVII, and chimeras)
Comparison
Chimeric Theiler's viruses with specific amino… vs Parental DA and GDVII strains, and chimeras…
Design
Preclinical
Authors
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No direct clinical implications from this animal model; leaves open VP2-141's role in human CNS viral persistence.
A single amino acid change at position 141 of the VP2 capsid protein is sufficient to confer the ability to persist and cause demyelination in chimeric Theiler's virus.
Jarousse et al. (1994) studied this question.
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