Population
Theiler's virus (a murine picornavirus) strains DA, BeAn, WW, GDVII, FA, and chimeric viruses
Comparison
Construction of chimeric viruses by exchanging… vs Wild-type DA and GDVII strains
Design
Preclinical
Authors
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VP1 segment determines Theiler's virus persistence in mice; leaves open relevance to human demyelinating disease or interventions.
The ability of Theiler's virus to persist and cause demyelination is determined by the VP1 capsid protein and a portion of protein 2A.
McAllister et al. (1990) studied this question.
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