February 1, 1990British Journal of PharmacologyOpen Access

The central and regional cardiovascular responses to intravenous and intracoronary administration of the phenyldihydropyridine elgodipine in anaesthetized pigs

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Why the study?

Does elgodipine alter central and regional cardiovascular hemodynamics in anaesthetized pigs?

Structured PICO

Does elgodipine alter central and regional cardiovascular hemodynamics in anaesthetized pigs?

Population

Anaesthetized pigs

Intervention

Intravenous (0.3, 1.0, 3.0 and 10.0 micrograms kg-1 min-1) and intracoronary (0.3, 0.9, 3.0 and 4.5 micrograms kg-1 min-1) infusions of elgodipine

Comparator

Solvent

Outcome

Central and regional cardiovascular responses (including arterial blood pressure, systemic vascular resistance, heart rate, LV dP/dtmax, left ventricular filling pressure, cardiac output, and segment length shortening)surrogate

Elgodipine acts as a potent systemic and coronary vasodilator without negative inotropic or positive chronotropic properties at intravenous doses, suggesting potential utility in cardiovascular diseases.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No change to practice from animal data; leaves open translation of selective vasodilation to human cardiovascular trials.

Cite This Study

Sassen et al. (1990) studied this question.

synapsesocial.com/papers/6a7e18e7bcaf28b5c937ed57 https://doi.org/10.1111/j.1476-5381.1990.tb14708.x

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Ask AI

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The central and regional cardiovascular responses to intravenous and intracoronary administration of the phenyldihydropyridine elgodipine in anaesthetized pigs

Structured PICO

Discussion

Implication

Cite This Study

The central and regional cardiovascular responses to intravenous and intracoronary administration of the phenyldihydropyridine elgodipine in anaesthetized pigs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider