May 26, 2017Scientific ReportsOpen Access

Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

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Why the study?

Does Astragaloside IV improve heart function and mitochondrial energy metabolism in a mouse model of pressure overload-induced heart failure?

Population

Mouse model of heart failure induced by transverse aortic constriction and isolated hypertrophic myocardial…

Comparison

Astragaloside IV administered at a low dose or… vs Sham surgery group and TAC group receiving no…

Design

Preclinical

Follow-up

8 weeks

Authors

ZDZhiwei DongWeifang Medical University PZPei ZhaoShanghai University of Traditional Chinese Medicine MXMing XuChina Mobile (China)

Discussion

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Implication

Provides hypothesis-generating evidence for metabolic modulation in pressure-overload heart failure.

Structured PICO

Does Astragaloside IV improve heart function and mitochondrial energy metabolism in a mouse model of pressure overload-induced heart failure?

Population

Mouse model of heart failure induced by transverse aortic constriction (TAC) and isolated hypertrophic myocardial cells.

Intervention

Astragaloside IV (AST) administered at a low dose (0.3 mg/kg/day) or high dose (1.0 mg/kg/day) starting one week after TAC surgery.

Comparator

Sham surgery group and TAC group receiving no AST treatment. A selective PPARα agonist (GW7647, 1 µg/g/day) was also used as a positive control.

Outcome

Heart function (fractional shortening, ejection fraction, hemodynamics), energy metabolism (fatty acid β-oxidation, glycolysis), and mitochondrial function (ATP production, oxygen consumption rate).surrogate

Astragaloside IV alleviates heart failure in a mouse model by activating PPARα to switch energy metabolism from glycolysis to fatty acid β-oxidation and improving mitochondrial function.

Cite This Study

Dong et al. (2017) studied this question.

synapsesocial.com/papers/6a7e1acfe8f153d930642888 https://doi.org/10.1038/s41598-017-02360-5

Topics

Heart failure HFrEF treatment

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Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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