December 23, 2003Hypertension

Endothelium-Derived Nitric Oxide Modulates Vascular Action of Aldosterone in Renal Arteriole

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Why the study?

Does endothelium-derived NO modulate the vasoconstrictor action of aldosterone in rabbit renal afferent arterioles?

Structured PICO

Does endothelium-derived NO modulate the vasoconstrictor action of aldosterone in rabbit renal afferent arterioles?

Population

Rabbit preglomerular afferent arterioles (Af-Arts) microperfused at 60 mm Hg in vitro

Intervention

Aldosterone (10(-10) to 10(-8) mol/L) added to bath and lumen, with or without endothelium disruption, NO synthesis inhibition, chelerythrine (PKC inhibitor), thapsigargin, or dantrolene

Comparator

Intact endothelium and absence of inhibitors

Outcome

Vasoconstriction (percentage decrease in intraluminal diameter) within 10 minutessurrogate

Endothelium-derived nitric oxide modulates the nongenomic vasoconstrictor actions of aldosterone in renal afferent arterioles, which are mediated by IP3 and PKC pathways.

Discussion

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Implication

Endothelial NO may blunt aldosterone vasoconstriction in animal renal arterioles; leaves open relevance to human hypertension.

Cite This Study

Arima et al. (2003) studied this question.

synapsesocial.com/papers/6a7e1bba23a0b6262dbf8602 https://doi.org/10.1161/01.hyp.0000111138.78714.1a

View Full Paper

Ask AI

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Endothelium-Derived Nitric Oxide Modulates Vascular Action of Aldosterone in Renal Arteriole

Structured PICO

Discussion

Implication

Cite This Study

Endothelium-Derived Nitric Oxide Modulates Vascular Action of Aldosterone in Renal Arteriole

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider