Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2012JAK-STATOpen Access

STAT transcription in the ischemic heart

View Full Paper
Ask AI
Bookmark
Share

Population

Ischemic heart disease models (including STAT3-deficient mice)

Design

Review

Authors

RKRichard A. KnightKPMG (United States)TSTiziano M. ScarabelliCollege of the Holy CrossASAnastasis StephanouInstitut polytechnique de Grenoble

Discussion

Loading...

Member takes

Implication

Opposing STAT1/STAT3 effects in ischemia support isoform-selective targeting; leaves open whether modulation improves post-MI outcomes.

Structured PICO

P
Population
Ischemic heart disease models (including STAT3-deficient mice)

STAT1 and STAT3 have opposing roles in acute ischemic injury, with STAT3 providing acute cardioprotection but contributing to chronic adverse remodeling and heart failure.

Cite This Study

Knight et al. (2012) studied this question.

synapsesocial.com/papers/6a7e1e40c82fecdb5194e3adhttps://doi.org/10.4161/jkst.20078
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biphasic Activation of the JAK/STAT Pathway by Angiotensin II in Rat Cardiomyocytes1998 · 113 citations
  2. 2Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning2004 · 128 citations
  3. 3Regulating RISK: a role for JAK-STAT signaling in postconditioning?2008 · 86 citations
  4. 4The functional role of the JAK–STAT pathway in post-infarction remodeling2002 · 78 citations
  5. 5The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3β2006 · 182 citations