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August 30, 2022Delta Journal of ScienceOpen Access

Omega-3 mitigates cardio-toxicity in male rats

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Why the study?

Doxorubicin is an anticancer drug with cardiotoxic effects, and omega-3 has shown biomedical potential that may mitigate this toxicity.

Does omega-3 mitigate doxorubicin-induced cardiotoxicity in male rats?

Population

Forty male rats

Comparison

DOX plus omega-3 vs DOX alone, omega-3 alone, and normal control

Design

Animal experimental study

Follow-up

a month

Authors

KEKarim Samy El-SaidTanta University

Discussion

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Implication

Omega-3 may attenuate DOX cardiotoxicity in rats; leaves open human translation pending clinical trials.

Structured PICO

Does omega-3 mitigate doxorubicin-induced cardiotoxicity in male rats?

P
Population
40 male rats (doxorubicin-induced cardiotoxicity model)
I
Intervention
Omega-3 (200 mg/kg) administered for a month
C
Comparator
Doxorubicin (4 mg/kg i.p. once a week for a month) alone, normal control, and omega-3 alone
O
Outcome
Hematological and biochemical parameters including cardiac functions and oxidative stress biomarkerssurrogate

Omega-3 supplementation may mitigate doxorubicin-induced cardiotoxicity based on preclinical rat models.

Cite This Study

Karim Samy El-Said (2022) studied this question.

synapsesocial.com/papers/6a7e2080aa9eee18675d7933https://doi.org/10.21608/djs.2022.151812.1033
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiotoxicity of doxorubicin and other anthracycline derivatives2000 · 133 citations
  2. 2Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes2012 · 172 citations
  3. 3Protective effect of omega-3 on Doxorubicin-induced hepatotoxicity in male albino rats2020 · 8 citations
  4. 4Chia Seed Oil Ameliorates Doxorubicin-Induced Cardiotoxicity in Female Wistar Rats: An Electrocardiographic, Biochemical and Histopathological Approach2021 · 54 citations
  5. 5Omega‐3 PUFA of marine origin limit diet‐induced obesity in mice by reducing cellularity of adipose tissue2004 · 329 citations