Why the study?
Aspirin has anti-inflammatory, antiplatelet, and direct antibacterial effects that may improve survival in sepsis, but the relationship between prehospital aspirin use and sepsis outcomes required evaluation.
Does prehospital aspirin use reduce 90-day mortality in patients with sepsis?
Population
52,982 patients with sepsis in Taiwan
Comparison
Prehospital aspirin use vs no prehospital antiplatelet agents
Design
Retrospective population-based cohort study
Follow-up
90 days
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Prehospital aspirin was associated with lower 90-day sepsis mortality; leaves open whether RCTs should test causality.
Does prehospital aspirin use reduce 90-day mortality in patients with sepsis?
Prehospital aspirin use is associated with a modest but statistically significant reduction in 90-day mortality among patients presenting with sepsis.
A 2022 study studied this question.
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