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January 1, 1997AJP Heart and Circulatory Physiology

Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart

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Population

Developing murine hearts (wild-type and phospholamban knockout mice)

Comparison

Targeted ablation of phospholamban and… vs Wild-type murine hearts

Design

Preclinical

Authors

JHJ HARRERKHKobra HaghighiHKHaeWon Kim

Discussion

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Overview

Supports phospholamban’s role in Ca2+ affinity during cardiac development; leaves open translation to human homeostasis.

Structured PICO

P
Population
Developing murine hearts (wild-type and phospholamban knockout mice)
I
Intervention
Targeted ablation of phospholamban and observation across developmental stages (birth to day 15)
C
Comparator
Wild-type murine hearts
O
Outcome
Expression levels of phospholamban and Ca(2+)-ATPase mRNA/protein and Ca2+ uptake affinitysurrogate

Coordinate regulation of phospholamban and Ca(2+)-ATPase expression is crucial for maintaining Ca2+ homeostasis in the developing mammalian heart.

Cite This Study

HARRER et al. (1997) studied this question.

synapsesocial.com/papers/6a7e261297cd01de9cb1f16dhttps://doi.org/10.1152/ajpheart.1997.272.1.h57
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.1994 · 715 citations
  2. 2Mouse phospholamban gene expression during development in vivo and in vitro.1992 · 65 citations
  3. 3Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.1996 · 328 citations
  4. 4Phospholamban Gene Dosage Effects in the Mammalian Heart1996 · 122 citations
  5. 5Differential Phospholamban Gene Expression in Murine Cardiac Compartments1995 · 62 citations