What question did this study set out to answer?

Evaluate the clinical utility, methodological limitations, and diagnostic performance of commercial insulin-like growth factor I (IGF-I) assays in assessing growth hormone deficiency.

January 1, 2001Hormone Research in Paediatrics

Commercial Assays Available for Insulin-Like Growth Factor I and Their Use in Diagnosing Growth Hormone Deficiency

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Authors

DCDavid R. ClemmonsUniversity of North Carolina at Chapel Hill

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Implication

Narrative review evaluates commercial insulin-like growth factor I assays in growth hormone disorders, indicating their utility in diagnosing deficiency and reducing provocative testing.

Key Points

Evaluate the clinical utility, methodological limitations, and diagnostic performance of commercial insulin-like growth factor I (IGF-I) assays in assessing growth hormone deficiency.
Reviewed commercial radioimmunoassays, two-site immunoradiometric sandwich assays (IRMA), and chemiluminescence methods used for IGF-I quantification.
Examined technical approaches to separate IGF-I from its binding proteins, including acid-ethanol extraction and saturation with IGF-II.
IGF-I assays show high diagnostic sensitivity and specificity for acromegaly, but screening for growth hormone deficiency remains less precise due to post-pubertal age variation and normative data deficits.
Two-site immunoradiometric and chemiluminescence assays provide superior speed, sensitivity, and specificity compared with older radioimmunoassays.
IGF-I measurement remains the most effective indirect tool for evaluating growth hormone deficiency, effectively monitoring hormone replacement therapy and reducing the necessity for provocative testing.

Cite This Study

David R. Clemmons (2001) studied this question.

synapsesocial.com/papers/6a7e268be978d321ec5d7a6f https://doi.org/10.1159/000063480

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Implication

Narrative review evaluates commercial insulin-like growth factor I assays in growth hormone disorders, indicating their utility in diagnosing deficiency and reducing provocative testing.

Commercial Assays Available for Insulin-Like Growth Factor I and Their Use in Diagnosing Growth Hormone Deficiency

Discussion

Member takes

Implication

Key Points

Cite This Study

Commercial Assays Available for Insulin-Like Growth Factor I and Their Use in Diagnosing Growth Hormone Deficiency

Discussion

Member takes

Implication

Key Points

Cite This Study

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