The ratio of CRP to albumin levels predict re-admission to intensive care unit in septic patients

Aim: Sepsis is associated with high mortality rates in the intensive care unit. The timely discharge of patients diagnosed with sepsis will reduce mortality and re-admissions thus prevent increased costs. Early discharge of intensive care patients causes the transfer of patients with severe diseases to the wards and may increase re-admission and mortality. Our study aims to evaluate the effectiveness of C-Reactive Protein and Albumin levels in the prediction of the re-admission of patients treated with sepsis in the intensive care unit. Material and methods: Patients who were treated for sepsis between December 2017 and December 2018 discharged to the ward from the intensive care unit were included within the study. Patient demographic results (age, gender), Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores, biochemical parameters, C-Reactive Protein, Albumin, C-Reactive Protein/Albumin ratios in admission and laboratory results and C-Reactive Protein, Albumin, C-Reactive Protein/Albumin ratios on the day of discharge were recorded both from intensive care unit patient-charts and hospital database. Results: 300 patients were included in our study. The mean age of the patients was 64±19 years, and the mean APACHE-II was 22±9. The re-admitting group had higher ages and APACHE-II. The C-Reactive Protein, Albumin, C-Reactive Protein/Albumin ratio levels of re-admitted patients were significantly different than discharged patients’ levels. In the Receiver Operational Curve analysis, C-Reactive Protein/Albumin ratio 23,5 was the cut-off value for re-admission. Male gender was significantly higher re-admission than females. Conclusion: C-Reactive Protein/Albumin ratio is a valuable marker for the prediction of the re-admission of patients with sepsis in intensive care unit after discharge.