Key result
Higher CRP/albumin ratio correlates with longer mechanical ventilation and ICU stays in critically ill patients.
Why the study?
The CRP/albumin ratio is a novel biomarker integrating two acute phase reactants, but its impact on clinical characteristics and outcomes in critically ill, mechanically ventilated adult patients required investigation.
Does the CRP/albumin ratio predict clinical characteristics and outcomes in critically ill and mechanically ventilated adult patients?
Observational (n=100)
Does the CRP/albumin ratio predict clinical characteristics and outcomes in critically ill and mechanically ventilated adult patients?
Effect estimate: r = 0.48
p-value: p=0.001
The CRP/albumin ratio serves as a significant prognostic biomarker for mechanical ventilation duration, ICU length of stay, and mortality in critically ill patients.
May inform prognosis in ventilated ICU patients; hypothesis-generating and requires prospective validation before clinical use.
Introduction: CPR/albumin ratio represents a new biomarker that integrates two laboratory-tested acute phase reactants: a positive one (C-reactive protein) and a negative one (albumin), and which can be used as an indicator of the severity, progression and outcome of various illnesses, including critical illnesses. In this retrospective study, we investigated the impact of the CRP/albumin ratio on the clinical characteristics and outcome of the treatment of critically ill and mechanically ventilated adult patients. Patients and methods: This retrospective study included 100 critically ill patients (65 % males and 35 % females; median age of 67) treated at the medical intensive care unit (ICU) which required the use of invasive mechanical ventilation. The primary diagnoses upon admission to the intensive care unit were: sepsis and septic shock (39 %), acute heart failure or worsening chronic heart failure (20 %), exacerbation of chronic obstructive pulmonary disease (16 %), pneumonia (11 %), acute kidney injury or the exacerbation of chronic kidney disease (7 %) and other conditions (7 %). Results: Correlation analysis showed a significant moderate positive correlation between CRP/albumin ratio and the duration of mechanical ventilation measured in hours (r = 0.48, p = 0.001) and the time spent in the intensive care unit, measured in days (r = 0.44, p = 0.001). The median of the CRP/albumin ratio was 58.77 and the patients in the above-the-median group had a higher SOFA score. In terms of the outcomes, it has been determined that the surviving patients (56 %) had a significantly lower CRP/albumin ratio compared to those that had not survived (44 %), which correlates with their SOFA scores as well. In the group of survivors, the correlation between the ratio of CRP/albumin and the SOFA score is positive and statistically significant (r = 0.29, p = 0.03), in the group non-survivoris (r= 0.45, p = 0.003.) Conclusion: Based on the results of our study, the CRP/albumin ratio has proved to be a good predictor of clinical characteristics and outcomes of critically ill and mechanically ventilated patients.
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Loinjak et al. (2023) conducted an observational in Critically ill and mechanically ventilated patients (n=100). CRP/albumin ratio was evaluated on Duration of mechanical ventilation (r = 0.48, p=0.001). The CRP/albumin ratio in critically ill, mechanically ventilated patients positively correlated with the duration of mechanical ventilation (r=0.48, p=0.001) and ICU stay (r=0.44, p=0.001).
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