Why the study?
Does intensive antihypertensive treatment reduce plasma irET-1 levels in black patients with uncontrolled high blood pressure?
Does intensive antihypertensive treatment reduce plasma irET-1 levels in black patients with uncontrolled high blood pressure?
Controlling high blood pressure in black hypertensive patients reduces elevated plasma endothelin-1 levels, suggesting ET-1 elevation is a consequence of hypertension rather than a cause.
BP control linked to irET-1 reduction; hypothesis-generating that ET-1 is consequence rather than cause in black hypertensives.
Plasma concentrations of immunoreactive endothelin-1 (irET-1) are significantly elevated in blacks with hypertension. In the present study, we investigated the effect of the regulation of high blood pressure on plasma irET-1 levels in black hypertensive individuals. After the initial blood samples were collected from 20 black patients with uncontrolled high blood pressure (Day 1), an intensive antihypertensive treatment was initiated, and the blood pressure and plasma irET-1 levels were monitored on days 2, 8, and 22. When the high blood pressure was brought under control with commonly used antihypertensive medications, plasma irET-1 concentrations dropped dramatically, suggesting that ET-1 concentrations rise as a consequence of high blood pressure in this study group.
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Ergul et al. (1998) studied this question.
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