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October 25, 2021Journal of Applied Toxicology

Integrating analysis of circular RNA and mRNA expression profiles in doxorubicin induced cardiotoxicity mice

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Why the study?

Doxorubicin-induced cardiotoxicity limits its clinical application, but the underlying mechanisms remain incompletely understood.

Population

Twelve mice

Comparison

Doxorubicin vs saline control

Design

Randomized animal study

Authors

XXXiaoqing XingZTZhenzhen TanXZXuran Zhi

Discussion

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Overview

Hypothesis-generating for circRNA biomarkers in doxorubicin cardiotoxicity; human validation required before clinical consideration.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Xing et al. (2021) studied this question.

synapsesocial.com/papers/6a7e27f03d987f2790256aa2https://doi.org/10.1002/jat.4257
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Transcriptome Analysis of Circular RNAs Between the Doxorubicin-Induced Cardiomyocytes and Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Treated Ones2024 · 2 citations
  2. 2Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced Cardiotoxicity2026
  3. 3Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced Cardiotoxicity2025
  4. 4Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity2018 · 34 citations
  5. 5A Specific Circulating MicroRNA Cluster Is Associated to Late Differential Cardiac Response to Doxorubicin-Induced Cardiotoxicity <i>In Vivo</i>2018 · 27 citations